Cargando…
Revealing electronic features governing hydrolysis of cephalosporins in the active site of the L1 metallo-β-lactamase
The QM/MM simulations followed by electron density feature analysis are carried out to deepen the understanding of the reaction mechanism of cephalosporin hydrolysis in the active site of the L1 metallo-β-lactamase. The differences in reactivity of ten similar cephalosporin compounds are explained b...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050041/ https://www.ncbi.nlm.nih.gov/pubmed/35496524 http://dx.doi.org/10.1039/c9ra10649a |