An investigation of the metabolic activity, isozyme contribution, species differences and potential drug–drug interactions of PI-103, and the identification of efflux transporters for PI-103-O-glucuronide in HeLa1A9 cells

PI-103 is a phosphatidylinositol 3-kinase inhibitor that includes multiple receptor affinity modifications, and it is also a therapeutic drug candidate primarily for human malignant tumors. However, its metabolic fate and potential drug–drug interactions involving human cytochrome P450 (CYP) and UDP...

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Detalles Bibliográficos
Autores principales: Gao, Li, Qin, Zifei, Zhang, Beibei, Yin, Zhao, Zhang, Xiaojian, Yang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050161/
https://www.ncbi.nlm.nih.gov/pubmed/35497201
http://dx.doi.org/10.1039/c9ra09906a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050161/
https://www.ncbi.nlm.nih.gov/pubmed/35497201
http://dx.doi.org/10.1039/c9ra09906a

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