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T54R mutation destabilizes the dimer of superoxide dismutase 1(T54R) by inducing steric clashes at the dimer interface
Mutations cause abnormalities in protein structure, function and oligomerization. Different mutations in the superoxide dismutase 1 (SOD1) protein cause its misfolding, loss of dimerization and aggravate its aggregation in the amyotrophic lateral sclerosis disease. In this study, we report the mecha...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050410/ https://www.ncbi.nlm.nih.gov/pubmed/35492906 http://dx.doi.org/10.1039/c9ra09870d |