Sphingolipid changes in Parkinson L444P GBA mutation fibroblasts promote α-synuclein aggregation

Intraneuronal accumulation of aggregated α-synuclein is a pathological hallmark of Parkinson’s disease. Therefore, mechanisms capable of promoting α-synuclein deposition bear important pathogenetic implications. Mutations of the glucocerebrosidase 1 (GBA) gene represent a prevalent Parkinson’s disea...

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Detalles Bibliográficos
Autores principales: Galvagnion, Céline, Marlet, Frederik Ravnkilde, Cerri, Silvia, Schapira, Anthony H V, Blandini, Fabio, Di Monte, Donato A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050548/
https://www.ncbi.nlm.nih.gov/pubmed/35362022
http://dx.doi.org/10.1093/brain/awab371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050548/
https://www.ncbi.nlm.nih.gov/pubmed/35362022
http://dx.doi.org/10.1093/brain/awab371

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