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Kronos scRT: a uniform framework for single-cell replication timing analysis

Mammalian genomes are replicated in a cell type-specific order and in coordination with transcription and chromatin organization. Currently, single-cell replication studies require individual processing of sorted cells, yielding a limited number (<100) of cells. Here, we develop Kronos scRT, a so...

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Detalles Bibliográficos
Autores principales: Gnan, Stefano, Josephides, Joseph M., Wu, Xia, Spagnuolo, Manuela, Saulebekova, Dalila, Bohec, Mylène, Dumont, Marie, Baudrin, Laura G., Fachinetti, Daniele, Baulande, Sylvain, Chen, Chun-Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050662/
https://www.ncbi.nlm.nih.gov/pubmed/35484127
http://dx.doi.org/10.1038/s41467-022-30043-x