Clinical and Nonclinical Disposition and In Vitro Drug-Drug Interaction Potential of Felcisetrag, a Highly Selective and Potent 5-HT(4) Receptor Agonist

BACKGROUND AND OBJECTIVE: Felcisetrag (previously TAK-954 or TD-8954) is a highly selective and potent 5-HT(4) receptor agonist in clinical development for prophylaxis and treatment of postoperative gastrointestinal dysfunction (POGD). The rat, dog, and human absorption, distribution, metabolism, an...

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Detalles Bibliográficos
Autores principales: Pusalkar, Sandeepraj, Chowdhury, Swapan K., Czerniak, Richard, Zhu, Xiaochun, Li, Yuexian, Balani, Suresh K., Ramsden, Diane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050781/
https://www.ncbi.nlm.nih.gov/pubmed/35157234
http://dx.doi.org/10.1007/s13318-021-00751-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050781/
https://www.ncbi.nlm.nih.gov/pubmed/35157234
http://dx.doi.org/10.1007/s13318-021-00751-8

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