Loss of SIRT1 inhibits hematopoietic stem cell aging and age-dependent mixed phenotype acute leukemia

Aging of hematopoietic stem cells (HSCs) is linked to various blood disorders and malignancies. SIRT1 has been implicated in healthy aging, but its role in HSC aging is poorly understood. Surprisingly, we found that Sirt1 knockout improved the maintenance of quiescence of aging HSCs and their functi...

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Detalles Bibliográficos
Autores principales: Wang, Zhiqiang, Zhang, Chunxiao, Warden, Charles David, Liu, Zheng, Yuan, Yate-Ching, Guo, Chao, Wang, Charles, Wang, Jinhui, Wu, Xiwei, Ermel, Richard, Vonderfecht, Steven L., Wang, Xiuli, Brown, Christine, Forman, Stephen, Yang, Yaling, James You, M., Chen, WenYong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051098/
https://www.ncbi.nlm.nih.gov/pubmed/35484199
http://dx.doi.org/10.1038/s42003-022-03340-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051098/
https://www.ncbi.nlm.nih.gov/pubmed/35484199
http://dx.doi.org/10.1038/s42003-022-03340-w

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