Cargando…

MyD88 in hepatic stellate cells enhances liver fibrosis via promoting macrophage M1 polarization

During liver fibrosis, quiescent HSCs (qHSCs) are activated to become activated HSCs (aHSCs)/myofibroblasts. The signal adapter MyD88, an essential component of TLR signaling, plays an important role in liver fibrosis. However, far less is known about the specific effects of MyD88 signaling in both...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Jie, Liu, Yu, Chen, Haiqiang, Yuan, Qi, Wang, Jinyan, Niu, Meng, Hou, Lingling, Gu, Jianchun, Zhang, Jinhua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051099/ https://www.ncbi.nlm.nih.gov/pubmed/35484116 http://dx.doi.org/10.1038/s41419-022-04802-z

Ejemplares similares

MyD88 in Macrophages Enhances Liver Fibrosis by Activation of NLRP3 Inflammasome in HSCs
por: Ge, Shuang, et al.
Publicado: (2021)

MyD88 in macrophages protects against colitis via inhibiting the activation of NLRP3 inflammasome in epithelial cells
por: Liu, Shi, et al.
Publicado: (2022)

Schisandrin B Attenuates Diabetic Cardiomyopathy by Targeting MyD88 and Inhibiting MyD88‐Dependent Inflammation
por: Luo, Wu, et al.
Publicado: (2022)

Alternative activation of macrophages by filarial nematodes is MyD88-independent
por: Mylonas, Katie J., et al.
Publicado: (2013)

Soyasaponins reduce inflammation by downregulating MyD88 expression and suppressing the recruitments of TLR4 and MyD88 into lipid rafts
por: Chen, Junbin, et al.
Publicado: (2020)

MyD88 and beyond: a perspective on MyD88-targeted therapeutic approach for modulation of host immunity
por: Saikh, Kamal U.
Publicado: (2021)

A MyD88 meddles with survival
por: Bashyam, Hema
Publicado: (2007)

Role of MyD88 in Adenovirus Keratitis
por: Zhou, Xiaohong, et al.
Publicado: (2016)

Dioscin alleviates alcoholic liver fibrosis by attenuating hepatic stellate cell activation via the TLR4/MyD88/NF-κB signaling pathway
por: Liu, Min, et al.
Publicado: (2015)

MyD88 deficiency aggravates the severity of acute pancreatitis by promoting MyD88-independent TRIF pathway-mediated necrosis
por: Yang, Du-Jiang, et al.
Publicado: (2022)

Hepatic MyD88 regulates liver inflammation by altering synthesis of oxysterols
por: Lefort, Charlotte, et al.
Publicado: (2019)

MyD88-Dependent Signaling Influences Fibrosis and Alternative Macrophage Activation during Staphylococcus aureus Biofilm Infection
por: Hanke, Mark L., et al.
Publicado: (2012)

MyD88 contribution to ocular surface homeostasis
por: Reins, Rose Y., et al.
Publicado: (2017)

Mechanism of MyD88S mediated signal termination
por: Pustelny, Katarzyna, et al.
Publicado: (2022)

A Novel Kindred with MyD88 Deficiency
por: Bucciol, Giorgia, et al.
Publicado: (2022)

Inhibition of MyD88 Signaling Skews Microglia/Macrophage Polarization and Attenuates Neuronal Apoptosis in the Hippocampus After Status Epilepticus in Mice
por: Liu, Jin-Tao, et al.
Publicado: (2018)

Mucus clearance, MyD88-dependent and MyD88-independent immunity modulate lung susceptibility to spontaneous bacterial infection and inflammation
por: Livraghi-Butrico, Alessandra, et al.
Publicado: (2012)

Identification and Function of Myeloid Differentiation Factor 88 (MyD88) in Litopenaeus vannamei
por: Zhang, Shuang, et al.
Publicado: (2012)

Author Correction: Dioscin alleviates alcoholic liver fibrosis by attenuating hepatic stellate cell activation via the TLR4/MyD88/NF-κB signaling pathway
por: Liu, Min, et al.
Publicado: (2020)

Nicotine Modulates MyD88-Dependent Signaling Pathway in Macrophages during Mycobacterial Infection
por: AlQasrawi, Dania, et al.
Publicado: (2020)

Syk-MyD88 Axis Is a Critical Determinant of Inflammatory-Response in Activated Macrophages
por: Yi, Young-Su, et al.
Publicado: (2021)

Inhibitory effects of berberine on proinflammatory M1 macrophage polarization through interfering with the interaction between TLR4 and MyD88
por: Gong, Jing, et al.
Publicado: (2019)

MyD88 Polymorphisms and Association with Susceptibility to Salmonella Pullorum
por: Liu, Xian-Qing, et al.
Publicado: (2015)

Lipopolysaccharide-induced NF-κB nuclear translocation is primarily dependent on MyD88, but TNFα expression requires TRIF and MyD88
por: Sakai, Jiro, et al.
Publicado: (2017)

Myeloid differentiation primary response gene (MyD) 88 signalling is not essential for intestinal fibrosis development
por: Lutz, C., et al.
Publicado: (2017)

Colorectal cancer development is affected by the ECM molecule EMILIN-2 hinging on macrophage polarization via the TLR-4/MyD88 pathway
por: Andreuzzi, Eva, et al.
Publicado: (2022)

MyD88 Associated ROS Generation Is Crucial for Lactobacillus Induced IL-12 Production in Macrophage
por: Ichikawa, Shintaro, et al.
Publicado: (2012)

Deletion of FADD in Macrophages and Granulocytes Results in RIP3- and MyD88-Dependent Systemic Inflammation
por: Schock, Suruchi N., et al.
Publicado: (2015)

MyD88-dependent signaling drives toll-like receptor-induced trained immunity in macrophages
por: Owen, Allison M., et al.
Publicado: (2022)

Myeloid Differentiation Factor 88 (MyD88)-Deficiency Increases Risk of Diabetes in Mice
por: Hosoi, Toru, et al.
Publicado: (2010)

From monogenic lupus to TLR7/MyD88-targeted therapy
por: Wang, Min, et al.
Publicado: (2022)

MyD88 predicts chemoresistance to paclitaxel in epithelial ovarian cancer
por: Silasi, Dan-Arin, et al.
Publicado: (2007)

MyD88-Dependent Pathways in Leukocytes Affect the Retina in Diabetes
por: Tang, Jie, et al.
Publicado: (2013)

MyD88: a central player in innate immune signaling
por: Deguine, Jacques, et al.
Publicado: (2014)

MyD88 and TLR4 Expression in Epithelial Ovarian Cancer
por: Block, Matthew S., et al.
Publicado: (2018)

MyD88 signalling is critical in the development of pancreatic cancer cachexia
por: Zhu, Xinxia, et al.
Publicado: (2019)

Inflammatory Role of TLR-MyD88 Signaling in Multiple Sclerosis
por: Zheng, Chao, et al.
Publicado: (2020)

Possible Involvement of MyD88 in Regulating Stress Response in Mice
por: Hosoi, Toru, et al.
Publicado: (2021)

Two Human MYD88 Variants, S34Y and R98C, Interfere with MyD88-IRAK4-Myddosome Assembly
por: George, Julie, et al.
Publicado: (2011)

lnc-MRGPRF-6:1 Promotes M1 Polarization of Macrophage and Inflammatory Response through the TLR4-MyD88-MAPK Pathway
por: Hu, Dan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_uq6micjfm87n2fjfdo69gadlo3