Structural insights into TRPV2 activation by small molecules

Transient receptor potential vanilloid 2 (TRPV2) is involved in many critical physiological and pathophysiological processes, making it a promising drug target. Here we present cryo-electron microscopy (cryo-EM) structures of rat TRPV2 in lipid nanodiscs activated by 2-aminoethoxydiphenyl borate (2-...

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Detalles Bibliográficos
Autores principales: Pumroy, Ruth A., Protopopova, Anna D., Fricke, Tabea C., Lange, Iris U., Haug, Ferdinand M., Nguyen, Phuong T., Gallo, Pamela N., Sousa, Bárbara B., Bernardes, Gonçalo J. L., Yarov-Yarovoy, Vladimir, Leffler, Andreas, Moiseenkova-Bell, Vera Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051106/
https://www.ncbi.nlm.nih.gov/pubmed/35484159
http://dx.doi.org/10.1038/s41467-022-30083-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051106/
https://www.ncbi.nlm.nih.gov/pubmed/35484159
http://dx.doi.org/10.1038/s41467-022-30083-3

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