Hypoxia-activated neuropeptide Y/Y5 receptor/RhoA pathway triggers chromosomal instability and bone metastasis in Ewing sarcoma

Adverse prognosis in Ewing sarcoma (ES) is associated with the presence of metastases, particularly in bone, tumor hypoxia and chromosomal instability (CIN). Yet, a mechanistic link between these factors remains unknown. We demonstrate that in ES, tumor hypoxia selectively exacerbates bone metastasi...

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Detalles Bibliográficos
Autores principales: Lu, Congyi, Mahajan, Akanksha, Hong, Sung-Hyeok, Galli, Susana, Zhu, Shiya, Tilan, Jason U., Abualsaud, Nouran, Adnani, Mina, Chung, Stacey, Elmansy, Nada, Rodgers, Jasmine, Rodriguez, Olga, Albanese, Christopher, Wang, Hongkun, Regan, Maureen, Zgonc, Valerie, Blancato, Jan, Krawczyk, Ewa, Gallicano, G. Ian, Girgis, Michael, Cheema, Amrita, Iżycka-Świeszewska, Ewa, Cavalli, Luciane R., Pack, Svetlana D., Kitlinska, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051212/
https://www.ncbi.nlm.nih.gov/pubmed/35484119
http://dx.doi.org/10.1038/s41467-022-29898-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051212/
https://www.ncbi.nlm.nih.gov/pubmed/35484119
http://dx.doi.org/10.1038/s41467-022-29898-x

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