Nitrileimines as an alternative to azides in base-mediated click [3 + 2] cycloaddition with methylene active nitriles

Nitrileimines were implemented in practical click protocols with oxopropanenitriles for the straightforward 5-amino-1H-pyrazole synthesis via 1,3-dipolar cycloaddition. The reaction proceeds at room temperature in a short time with base catalysis and no chromatographic purification. High purity prod...

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Detalles Bibliográficos
Autores principales: Tupychak, Mykola A., Shyyka, Olga Ya., Pokhodylo, Nazariy T., Obushak, Mykola D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051556/
https://www.ncbi.nlm.nih.gov/pubmed/35493004
http://dx.doi.org/10.1039/d0ra01417f
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author Tupychak, Mykola A.
Shyyka, Olga Ya.
Pokhodylo, Nazariy T.
Obushak, Mykola D.
author_facet Tupychak, Mykola A.
Shyyka, Olga Ya.
Pokhodylo, Nazariy T.
Obushak, Mykola D.
author_sort Tupychak, Mykola A.
collection PubMed
description Nitrileimines were implemented in practical click protocols with oxopropanenitriles for the straightforward 5-amino-1H-pyrazole synthesis via 1,3-dipolar cycloaddition. The reaction proceeds at room temperature in a short time with base catalysis and no chromatographic purification. High purity products were isolated by simple filtration. The selectivity of the reaction was observed.
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spelling pubmed-90515562022-04-29 Nitrileimines as an alternative to azides in base-mediated click [3 + 2] cycloaddition with methylene active nitriles Tupychak, Mykola A. Shyyka, Olga Ya. Pokhodylo, Nazariy T. Obushak, Mykola D. RSC Adv Chemistry Nitrileimines were implemented in practical click protocols with oxopropanenitriles for the straightforward 5-amino-1H-pyrazole synthesis via 1,3-dipolar cycloaddition. The reaction proceeds at room temperature in a short time with base catalysis and no chromatographic purification. High purity products were isolated by simple filtration. The selectivity of the reaction was observed. The Royal Society of Chemistry 2020-04-03 /pmc/articles/PMC9051556/ /pubmed/35493004 http://dx.doi.org/10.1039/d0ra01417f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Tupychak, Mykola A.
Shyyka, Olga Ya.
Pokhodylo, Nazariy T.
Obushak, Mykola D.
Nitrileimines as an alternative to azides in base-mediated click [3 + 2] cycloaddition with methylene active nitriles
title Nitrileimines as an alternative to azides in base-mediated click [3 + 2] cycloaddition with methylene active nitriles
title_full Nitrileimines as an alternative to azides in base-mediated click [3 + 2] cycloaddition with methylene active nitriles
title_fullStr Nitrileimines as an alternative to azides in base-mediated click [3 + 2] cycloaddition with methylene active nitriles
title_full_unstemmed Nitrileimines as an alternative to azides in base-mediated click [3 + 2] cycloaddition with methylene active nitriles
title_short Nitrileimines as an alternative to azides in base-mediated click [3 + 2] cycloaddition with methylene active nitriles
title_sort nitrileimines as an alternative to azides in base-mediated click [3 + 2] cycloaddition with methylene active nitriles
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051556/
https://www.ncbi.nlm.nih.gov/pubmed/35493004
http://dx.doi.org/10.1039/d0ra01417f
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