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Microbiota-mediated skewing of tryptophan catabolism modulates CD4(+) T cells in lupus-prone mice
A skewed tryptophan metabolism has been reported in patients with lupus. Here, we investigated the mechanisms by which it occurs in lupus-susceptible mice, and how tryptophan metabolites exacerbate T cell activation. Metabolomic analyses demonstrated that tryptophan is differentially catabolized in...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051618/ https://www.ncbi.nlm.nih.gov/pubmed/35494242 http://dx.doi.org/10.1016/j.isci.2022.104241 |