Microbiota-mediated skewing of tryptophan catabolism modulates CD4(+) T cells in lupus-prone mice

A skewed tryptophan metabolism has been reported in patients with lupus. Here, we investigated the mechanisms by which it occurs in lupus-susceptible mice, and how tryptophan metabolites exacerbate T cell activation. Metabolomic analyses demonstrated that tryptophan is differentially catabolized in...

Descripción completa

Detalles Bibliográficos
Autores principales: Brown, Josephine, Abboud, Georges, Ma, Longhuan, Choi, Seung-Chul, Kanda, Nathalie, Zeumer-Spataro, Leilani, Lee, Jean, Peng, Weidan, Cagmat, Joy, Faludi, Tamas, Mohamadzadeh, Mansour, Garrett, Timothy, Mandik-Nayak, Laura, Chervonsky, Alexander, Perl, Andras, Morel, Laurence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051618/
https://www.ncbi.nlm.nih.gov/pubmed/35494242
http://dx.doi.org/10.1016/j.isci.2022.104241

Ejemplares similares

Ejemplares similares