A single phenylalanine residue in β-arrestin2 critically regulates its binding to G protein–coupled receptors

Arrestins and their yeast homologs, arrestin-related trafficking adaptors (ARTs), share a stretch of 29 amino acids called the ART motif. However, the functionality of that motif is unknown. We now report that deleting this motif prevents agonist-induced ubiquitination of β-arrestin2 (β-arr2) and bl...

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Detalles Bibliográficos
Autores principales: Jean-Charles, Pierre-Yves, Rajiv, Vishwaesh, Sarker, Subhodeep, Han, Sangoh, Bai, Yushi, Masoudi, Ali, Shenoy, Sudha K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052155/
https://www.ncbi.nlm.nih.gov/pubmed/35307348
http://dx.doi.org/10.1016/j.jbc.2022.101837

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052155/
https://www.ncbi.nlm.nih.gov/pubmed/35307348
http://dx.doi.org/10.1016/j.jbc.2022.101837

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