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Downregulation of the endothelial histone demethylase JMJD3 is associated with neointimal hyperplasia of arteriovenous fistulas in kidney failure

Jumonji domain–containing protein-3 (JMJD3), a histone H3 lysine 27 (H3K27) demethylase, promotes endothelial regeneration, but its function in neointimal hyperplasia (NIH) of arteriovenous fistulas (AVFs) has not been explored. In this study, we examined the contribution of endothelial JMJD3 to NIH...

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Detalles Bibliográficos
Autores principales: Feng, Shaozhen, Peden, Eric K., Guo, Qunying, Lee, Tae Hoon, Li, Qingtian, Yuan, Yuhui, Chen, Changyi, Huang, Fengzhang, Cheng, Jizhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052161/
https://www.ncbi.nlm.nih.gov/pubmed/35278430
http://dx.doi.org/10.1016/j.jbc.2022.101816