Synthesis and in vitro anti-proliferative evaluation of naphthalimide–chalcone/pyrazoline conjugates as potential SERMs with computational validation

A series of naphthalimide-chalcone/pyrazoline conjugates was prepared and evaluated for their anti-breast cancer potential against estrogen responsive, i.e. MCF-7 (ER+), and triple-negative, i.e. MDA-MB-231 (ER−), cell lines. The structure-activity-relationship (SAR) was deduced based on the influen...

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Detalles Bibliográficos
Autores principales: Shalini, Pankaj, Saha, Sourav Taru, Kaur, Mandeep, Oluwakemi, Ebenezer, Awolade, Paul, Singh, Parvesh, Kumar, Vipan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052575/
https://www.ncbi.nlm.nih.gov/pubmed/35493668
http://dx.doi.org/10.1039/d0ra01822h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052575/
https://www.ncbi.nlm.nih.gov/pubmed/35493668
http://dx.doi.org/10.1039/d0ra01822h

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