The compound LG283 inhibits bleomycin-induced skin fibrosis via antagonizing TGF-β signaling

BACKGROUND: Systemic sclerosis (SSc) is a collagen disease that exhibits intractable fibrosis and vascular injury of the skin and internal organs. Transforming growth factor-β (TGF-β)/Smad signaling plays a central role in extracellular matrix (ECM) production by α-SMA-positive myofibroblasts. Myofi...

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Detalles Bibliográficos
Autores principales: Utsunomiya, Akira, Chino, Takenao, Kasamatsu, Hiroshi, Hasegawa, Takumi, Utsunomiya, Natsuko, Luong, Vu Huy, Matsushita, Takashi, Sasaki, Yoko, Ogura, Dai, Niwa, Shin-ichiro, Oyama, Noritaka, Hasegawa, Minoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052694/
https://www.ncbi.nlm.nih.gov/pubmed/35488265
http://dx.doi.org/10.1186/s13075-022-02773-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052694/
https://www.ncbi.nlm.nih.gov/pubmed/35488265
http://dx.doi.org/10.1186/s13075-022-02773-2

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