Profiling the Landscape of Drug Resistance Mutations in Neosubstrates to Molecular Glue Degraders

[Image: see text] Targeted protein degradation (TPD) holds immense promise for drug discovery, but mechanisms of acquired resistance to degraders remain to be fully identified. Here, we used clustered regularly interspaced short palindromic repeats (CRISPR)-suppressor scanning to identify mechanisti...

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Detalles Bibliográficos
Autores principales: Gosavi, Pallavi M., Ngan, Kevin C., Yeo, Megan J. R., Su, Cindy, Li, Jiaming, Lue, Nicholas Z., Hoenig, Samuel M., Liau, Brian B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052798/
https://www.ncbi.nlm.nih.gov/pubmed/35505873
http://dx.doi.org/10.1021/acscentsci.1c01603

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052798/
https://www.ncbi.nlm.nih.gov/pubmed/35505873
http://dx.doi.org/10.1021/acscentsci.1c01603

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