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Profiling the Landscape of Drug Resistance Mutations in Neosubstrates to Molecular Glue Degraders
[Image: see text] Targeted protein degradation (TPD) holds immense promise for drug discovery, but mechanisms of acquired resistance to degraders remain to be fully identified. Here, we used clustered regularly interspaced short palindromic repeats (CRISPR)-suppressor scanning to identify mechanisti...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052798/ https://www.ncbi.nlm.nih.gov/pubmed/35505873 http://dx.doi.org/10.1021/acscentsci.1c01603 |