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Redirecting RiPP Biosynthetic Enzymes to Proteins and Backbone-Modified Substrates

[Image: see text] Ribosomally synthesized and post-translationally modified peptides (RiPPs) are peptide-derived natural products with potent antibiotic, antiviral, and anticancer properties. RiPP enzymes known as cyclodehydratases and dehydrogenases work together to catalyze intramolecular, inter-r...

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Detalles Bibliográficos
Autores principales: Walker, Joshua A., Hamlish, Noah, Tytla, Avery, Brauer, Daniel D., Francis, Matthew B., Schepartz, Alanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052802/
https://www.ncbi.nlm.nih.gov/pubmed/35505866
http://dx.doi.org/10.1021/acscentsci.1c01577