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Redirecting RiPP Biosynthetic Enzymes to Proteins and Backbone-Modified Substrates
[Image: see text] Ribosomally synthesized and post-translationally modified peptides (RiPPs) are peptide-derived natural products with potent antibiotic, antiviral, and anticancer properties. RiPP enzymes known as cyclodehydratases and dehydrogenases work together to catalyze intramolecular, inter-r...
Autores principales: | Walker, Joshua A., Hamlish, Noah, Tytla, Avery, Brauer, Daniel D., Francis, Matthew B., Schepartz, Alanna |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052802/ https://www.ncbi.nlm.nih.gov/pubmed/35505866 http://dx.doi.org/10.1021/acscentsci.1c01577 |
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