Induction of ADCC by a folic acid–mAb conjugate prepared by tryptophan-selective reaction toward folate-receptor-positive cancer cells

We developed conjugates between monoclonal antibody (mAb) and folic acid (FA) by using a tryptophan (Trp)-selective reaction, which yields relatively homogenous products compared to conventional methods. The obtained mAb–FA conjugates showed significant cellular cytotoxicity toward folate receptor-e...

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Detalles Bibliográficos
Autores principales: Tagawa, Hiroshi, Maruyama, Katsuya, Sasaki, Koichi, Konoue, Natsuki, Kishimura, Akihiro, Kanai, Motomu, Mori, Takeshi, Oisaki, Kounosuke, Katayama, Yoshiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053046/
https://www.ncbi.nlm.nih.gov/pubmed/35498849
http://dx.doi.org/10.1039/d0ra03291c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053046/
https://www.ncbi.nlm.nih.gov/pubmed/35498849
http://dx.doi.org/10.1039/d0ra03291c

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