Cargando…

Induction of ADCC by a folic acid–mAb conjugate prepared by tryptophan-selective reaction toward folate-receptor-positive cancer cells

We developed conjugates between monoclonal antibody (mAb) and folic acid (FA) by using a tryptophan (Trp)-selective reaction, which yields relatively homogenous products compared to conventional methods. The obtained mAb–FA conjugates showed significant cellular cytotoxicity toward folate receptor-e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tagawa, Hiroshi, Maruyama, Katsuya, Sasaki, Koichi, Konoue, Natsuki, Kishimura, Akihiro, Kanai, Motomu, Mori, Takeshi, Oisaki, Kounosuke, Katayama, Yoshiki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2020
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053046/ https://www.ncbi.nlm.nih.gov/pubmed/35498849 http://dx.doi.org/10.1039/d0ra03291c

Ejemplares similares

Chemo- and regioselective oxygenation of C(sp(3))–H bonds in aliphatic alcohols using a covalently bound directing activator and atmospheric oxygen
por: Ozawa, Jun, et al.
Publicado: (2016)

Glyco-engineered anti-EGFR mAb elicits ADCC by NK cells from colorectal cancer patients irrespective of chemotherapy
por: Oppenheim, D E, et al.
Publicado: (2014)

Practical N-to-C peptide synthesis with minimal protecting groups
por: Tatsumi, Toshifumi, et al.
Publicado: (2023)

SEPPA-mAb: spatial epitope prediction of protein antigens for mAbs
por: Qiu, Tianyi, et al.
Publicado: (2023)

Fc-binding antibody-recruiting molecules exploit endogenous antibodies for anti-tumor immune responses
por: Sasaki, Koichi, et al.
Publicado: (2020)

Anti-HER2 mAb plus calicheamicin immunoconjugate linked on liposomal vinorelbine induces ADCC and apoptosis in HER2-positive high grade DCIS
por: Giannos, J, et al.
Publicado: (2000)

Protective mAbs and Cross-Reactive mAbs Raised by Immunization with Engineered Marburg Virus GPs
por: Fusco, Marnie L., et al.
Publicado: (2015)

The Different Colors of mAbs in Solution
por: Ambrogelly, Alexandre
Publicado: (2021)

Correction: Protective mAbs and Cross-Reactive mAbs Raised by Immunization with Engineered Marburg Virus GPs
por: Fusco, Marnie L., et al.
Publicado: (2015)

Oxidation of specific tryptophan residues inhibits high-affinity binding of cocaine and its metabolites to a humanized anticocaine mAb
por: Kirley, Terence L., et al.
Publicado: (2022)

Cellular tools for biosimilar mAb analysis
por: Lindemann, Carsten, et al.
Publicado: (2013)

Evolving trends in mAb production processes
por: Shukla, Abhinav A., et al.
Publicado: (2017)

State of the art in anti-cancer mAbs
por: Chiavenna, S. M., et al.
Publicado: (2017)

Non invasive imaging assessment of the biodistribution of GSK2849330, an ADCC and CDC optimized anti HER3 mAb, and its role in tumor macrophage recruitment in human tumor-bearing mice
por: Alsaid, Hasan, et al.
Publicado: (2017)

Stability enhancement in a mAb and Fab coformulation
por: Zhang, Hongyu, et al.
Publicado: (2020)

Pan-sarbecovirus mAb protects from variants
por: Flemming, Alexandra
Publicado: (2021)

A mAb for the detection of the antiretroviral drug emtricitabine
por: Youngpairoj, Ae S., et al.
Publicado: (2022)

Folates, folic acid and preconception care – a review
por: House, Simon H, et al.
Publicado: (2021)

Intake of dietary folate and folic acid in Germany based on different scenarios for food fortification with folic acid
por: Martiniak, Yvonne, et al.
Publicado: (2014)

Folate during reproduction: the Canadian experience with folic acid fortification
por: Lindzon, Gillian, et al.
Publicado: (2007)

Excessive Folic Acid Mimics Folate Deficiency in Human Lymphocytes
por: Alnabbat, Khadijah I., et al.
Publicado: (2022)

Dynamic frustrated charge hotspots created by charge density modulation sequester globular proteins into complex coacervates
por: K C, Biplab, et al.
Publicado: (2023)

Novel strategy for a high-yielding mAb-producing CHO strain (overexpression of non-coding RNA enhanced proliferation and improved mAb yield)
por: Tabuchi, Hisahiro
Publicado: (2013)

Effect of Size and Loading of Retinoic Acid in Polyvinyl Butyrate Nanoparticles on Amelioration of Colitis
por: Li, Jinting, et al.
Publicado: (2021)

Developmental changes in heparan sulfate expression: in situ detection with mAbs
Publicado: (1992)

Direct analysis of mAb aggregates in mammalian cell culture supernatant
por: Paul, Albert J, et al.
Publicado: (2014)

Conservancy of mAb Epitopes in Ebolavirus Glycoproteins of Previous and 2014 Outbreaks
por: Ponomarenko, Julia, et al.
Publicado: (2014)

Self-Interaction Chromatography of mAbs: Accurate Measurement of Dead Volumes
por: Hedberg, S. H. M., et al.
Publicado: (2015)

Anti-GD2 mAb and Vorinostat synergize in the treatment of neuroblastoma
por: Kroesen, Michiel, et al.
Publicado: (2016)

Germinality does not necessarily define mAb expression and thermal stability
por: Schwaigerlehner, Linda, et al.
Publicado: (2019)

The Role of Complement in the Mechanism of Action of Therapeutic Anti-Cancer mAbs
por: Golay, Josée, et al.
Publicado: (2020)

Circulating Unmetabolized Folic Acid: Relationship to Folate Status and Effect of Supplementation
por: Tam, Carolyn, et al.
Publicado: (2012)

Detectable Unmetabolized Folic Acid and Elevated Folate Concentrations in Folic Acid-Supplemented Canadian Children With Sickle Cell Disease
por: Williams, Brock A., et al.
Publicado: (2021)

Preparation of a PEGylated liposome that co-encapsulates l-arginine and doxorubicin to achieve a synergistic anticancer effect
por: Feng, Haitao, et al.
Publicado: (2021)

Endoplasmic reticulum retention motif fused to recombinant anti-cancer monoclonal antibody (mAb) CO17-1A affects mAb expression and plant stress response
por: Song, Ilchan, et al.
Publicado: (2018)

Folate Catabolites in Spot Urine as Non-Invasive Biomarkers of Folate Status during Habitual Intake and Folic Acid Supplementation
por: Niesser, Mareile, et al.
Publicado: (2013)

Strategies for adaptation of mAb-producing CHO cells to serum-free medium
por: Costa, A Rita, et al.
Publicado: (2011)

Successful radioimmunotherapy of established syngeneic rat colon carcinoma with (211)At-mAb
por: Eriksson, Sophie E, et al.
Publicado: (2013)

Characterization of mAb aggregates in a mammalian cell culture production process
por: Paul, Albert, et al.
Publicado: (2013)

Characterization of Two Novel mAbs Recognizing Different Epitopes on CD43
por: Kim, Soseul, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_naemq57kvcu77qdmuuc96mv3nc