Specific ablation of PDGFRβ-overexpressing pericytes with antibody-drug conjugate potently inhibits pathologic ocular neovascularization in mouse models

BACKGROUND: Crosstalk between pericytes and endothelial cells is critical for ocular neovascularization. Endothelial cells secrete platelet-derived growth factor (PDGF)-BB and recruit PDGF receptor β (PDGFRβ)–overexpressing pericytes, which in turn cover and stabilize neovessels, independent of vasc...

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Detalles Bibliográficos
Autores principales: Lee, Seok Jae, Kim, Soohyun, Jo, Dong Hyun, Cho, Chang Sik, Kim, Su Ree, Kang, Dongmin, Chae, Jisu, Yoo, Duck Kyun, Ha, Suji, Chung, Junho, Kim, Jeong Hun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053257/
https://www.ncbi.nlm.nih.gov/pubmed/35602228
http://dx.doi.org/10.1038/s43856-021-00059-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053257/
https://www.ncbi.nlm.nih.gov/pubmed/35602228
http://dx.doi.org/10.1038/s43856-021-00059-3

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