A concise and sequential synthesis of the nitroimidazooxazole based drug, Delamanid and related compounds

A concise, protection-group free and sequential route has been developed for the synthesis of the nitroimidazole based FDA-approved multi-drug resistant anti-tuberculosis drug, Delamanid and anti-leishmanial lead candidate VL-2098. The synthesis required chiral epoxides (11 and 17) as key intermedia...

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Detalles Bibliográficos
Autores principales: Sharma, Sumit, Anand, Radhika, Cham, Pankaj Singh, Raina, Sushil, Vishwakarma, Ram. A., Singh, Parvinder Pal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053479/
https://www.ncbi.nlm.nih.gov/pubmed/35521460
http://dx.doi.org/10.1039/d0ra01662d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053479/
https://www.ncbi.nlm.nih.gov/pubmed/35521460
http://dx.doi.org/10.1039/d0ra01662d

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