Development of novel N-(6-methanesulfonyl-benzothiazol-2-yl)-3-(4-substituted-piperazin-1-yl)-propionamides with cholinesterase inhibition, anti-β-amyloid aggregation, neuroprotection and cognition enhancing properties for the therapy of Alzheimer's disease

A novel series of benzothiazole–piperazine hybrids were rationally designed, synthesized, and evaluated as multifunctional ligands against Alzheimer's disease (AD). The synthesized hybrid molecules illustrated modest to strong inhibition of acetylcholinesterase (AChE) and Aβ(1-42) aggregation....

Descripción completa

Detalles Bibliográficos
Autores principales: Mishra, Chandra Bhushan, Shalini, Shruti, Gusain, Siddharth, Prakash, Amresh, Kumari, Jyoti, Kumari, Shikha, Yadav, Anita Kumari, Lynn, Andrew M., Tiwari, Manisha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053591/
https://www.ncbi.nlm.nih.gov/pubmed/35515597
http://dx.doi.org/10.1039/d0ra00663g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053591/
https://www.ncbi.nlm.nih.gov/pubmed/35515597
http://dx.doi.org/10.1039/d0ra00663g

Ejemplares similares