Synthesis of heteroatom-containing pyrrolidine derivatives based on Ti(O-iPr)(4) and EtMgBr-catalyzed carbocyclization of allylpropargyl amines with Et(2)Zn

The Ti(O-iPr)(4) and EtMgBr-catalyzed regio and stereoselective carbocyclization of N-allyl-substituted 2-alkynylamines with Et(2)Zn, followed by deuterolysis or hydrolysis, affords the corresponding methylenepyrrolidine derivatives in high yields. It was found that Ti–Mg-catalyzed carbocyclization...

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Detalles Bibliográficos
Autores principales: Kadikova, Rita N., Ramazanov, Ilfir R., Gabdullin, Azat M., Mozgovoj, Oleg S., Dzhemilev, Usein M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053609/
https://www.ncbi.nlm.nih.gov/pubmed/35515579
http://dx.doi.org/10.1039/d0ra02677h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053609/
https://www.ncbi.nlm.nih.gov/pubmed/35515579
http://dx.doi.org/10.1039/d0ra02677h

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