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Synthesis of heteroatom-containing pyrrolidine derivatives based on Ti(O-iPr)(4) and EtMgBr-catalyzed carbocyclization of allylpropargyl amines with Et(2)Zn
The Ti(O-iPr)(4) and EtMgBr-catalyzed regio and stereoselective carbocyclization of N-allyl-substituted 2-alkynylamines with Et(2)Zn, followed by deuterolysis or hydrolysis, affords the corresponding methylenepyrrolidine derivatives in high yields. It was found that Ti–Mg-catalyzed carbocyclization...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053609/ https://www.ncbi.nlm.nih.gov/pubmed/35515579 http://dx.doi.org/10.1039/d0ra02677h |