A targeted neurotransmitter quantification and nontargeted metabolic profiling method for pharmacometabolomics analysis of olanzapine by using UPLC-HRMS

Neurotransmitters (NTs) are specific endogenous metabolites that act as “messengers” in synaptic transmission and are widely distributed in the central nervous system. Olanzapine (OLZ), a first-line antipsychotic drug, plays a key role in sedation and hypnosis, but, it presents clinical problems wit...

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Detalles Bibliográficos
Autores principales: Liu, Dan, An, Zhuoling, Li, Pengfei, Chen, Yanhua, Zhang, Ruiping, Liu, Lihong, He, Jiuming, Abliz, Zeper
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053711/
https://www.ncbi.nlm.nih.gov/pubmed/35517196
http://dx.doi.org/10.1039/d0ra02406f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053711/
https://www.ncbi.nlm.nih.gov/pubmed/35517196
http://dx.doi.org/10.1039/d0ra02406f

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