Studies on asymmetric total synthesis of (−)-β-hydrastine via a chiral epoxide ring-opening cascade cyclization strategy

Herein, facile and enantioselective approaches to synthesize the core phthalide tetrahydroisoquinoline scaffold of (−)-β-hydrastine via both a CF(3)COOH-catalyzed (86% ee) and KHMDS-catalyzed (78% ee) epoxide ring-opening/transesterification cascade cyclization from chiral epoxide under very mild co...

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Detalles Bibliográficos
Autores principales: Li, Jihui, Wu, Tianxiao, Song, Xinjing, Zheng, Yang, Meng, Jiaxin, Qin, Qiaohua, Liu, Yongxiang, Zhao, Dongmei, Cheng, Maosheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053876/
https://www.ncbi.nlm.nih.gov/pubmed/35518292
http://dx.doi.org/10.1039/d0ra03038d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053876/
https://www.ncbi.nlm.nih.gov/pubmed/35518292
http://dx.doi.org/10.1039/d0ra03038d

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