High-resolution profiling of MHC II peptide presentation capacity reveals SARS-CoV-2 CD4 T cell targets and mechanisms of immune escape

Understanding peptide presentation by specific MHC alleles is fundamental for controlling physiological functions of T cells and harnessing them for therapeutic use. However, commonly used in silico predictions and mass spectroscopy have their limitations in precision, sensitivity, and throughput, p...

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Detalles Bibliográficos
Autores principales: Obermair, Franz-Josef, Renoux, Florian, Heer, Sebastian, Lee, Chloe H., Cereghetti, Nastassja, Loi, Marisa, Maestri, Giulia, Haldner, Yannick, Wuigk, Robin, Iosefson, Ohad, Patel, Pooja, Triebel, Katherine, Kopf, Manfred, Swain, Joanna, Kisielow, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054008/
https://www.ncbi.nlm.nih.gov/pubmed/35486722
http://dx.doi.org/10.1126/sciadv.abl5394

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054008/
https://www.ncbi.nlm.nih.gov/pubmed/35486722
http://dx.doi.org/10.1126/sciadv.abl5394

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