A novel β-catenin/BCL9 complex inhibitor blocks oncogenic Wnt signaling and disrupts cholesterol homeostasis in colorectal cancer

Dysregulated Wnt/β-catenin signaling is implicated in the pathogenesis of many human cancers, including colorectal cancer (CRC), making it an attractive clinical target. With the aim of inhibiting oncogenic Wnt activity, we developed a high-throughput screening AlphaScreen assay to identify selectiv...

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Detalles Bibliográficos
Autores principales: Tanton, Helen, Sewastianik, Tomasz, Seo, Hyuk-Soo, Remillard, David, Pierre, Roodolph St., Bala, Pratyusha, Aitymbayev, Daulet, Dennis, Peter, Adler, Keith, Geffken, Ezekiel, Yeoh, Zoe, Vangos, Nicholas, Garbicz, Filip, Scott, David, Sethi, Nilay, Bradner, James, Dhe-Paganon, Sirano, Carrasco, Ruben D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054024/
https://www.ncbi.nlm.nih.gov/pubmed/35486727
http://dx.doi.org/10.1126/sciadv.abm3108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054024/
https://www.ncbi.nlm.nih.gov/pubmed/35486727
http://dx.doi.org/10.1126/sciadv.abm3108

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