A NAC domain mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity

The alpha-synuclein mutation E83Q, the first in the NAC domain of the protein, was recently identified in a patient with dementia with Lewy bodies. We investigated the effects of this mutation on the aggregation of aSyn monomers and the structure, morphology, dynamic, and seeding activity of the aSy...

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Detalles Bibliográficos
Autores principales: Kumar, Senthil T., Mahul-Mellier, Anne-Laure, Hegde, Ramanath Narayana, Rivière, Gwladys, Moons, Rani, Ibáñez de Opakua, Alain, Magalhães, Pedro, Rostami, Iman, Donzelli, Sonia, Sobott, Frank, Zweckstetter, Markus, Lashuel, Hilal A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054026/
https://www.ncbi.nlm.nih.gov/pubmed/35486726
http://dx.doi.org/10.1126/sciadv.abn0044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054026/
https://www.ncbi.nlm.nih.gov/pubmed/35486726
http://dx.doi.org/10.1126/sciadv.abn0044

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