Cargando…

A NAC domain mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity

The alpha-synuclein mutation E83Q, the first in the NAC domain of the protein, was recently identified in a patient with dementia with Lewy bodies. We investigated the effects of this mutation on the aggregation of aSyn monomers and the structure, morphology, dynamic, and seeding activity of the aSy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kumar, Senthil T., Mahul-Mellier, Anne-Laure, Hegde, Ramanath Narayana, Rivière, Gwladys, Moons, Rani, Ibáñez de Opakua, Alain, Magalhães, Pedro, Rostami, Iman, Donzelli, Sonia, Sobott, Frank, Zweckstetter, Markus, Lashuel, Hilal A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054026/ https://www.ncbi.nlm.nih.gov/pubmed/35486726 http://dx.doi.org/10.1126/sciadv.abn0044

Ejemplares similares

Revisiting the specificity and ability of phospho-S129 antibodies to capture alpha-synuclein biochemical and pathological diversity
por: Lashuel, Hilal A., et al.
Publicado: (2022)

Inhibition of α-Synuclein Fibrillization by Dopamine Is Mediated by Interactions with Five C-Terminal Residues and with E83 in the NAC Region
por: Herrera, Fernando E., et al.
Publicado: (2008)

O-GlcNAc modification forces the formation of an α-Synuclein amyloid-strain with notably diminished seeding activity and pathology
por: Balana, Aaron T., et al.
Publicado: (2023)

Amyloid single-cell cytotoxicity assays by nanomotion detection
por: Ruggeri, Francesco S, et al.
Publicado: (2017)

The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration
por: Mahul-Mellier, Anne-Laure, et al.
Publicado: (2020)

A simple, versatile and robust centrifugation‐based filtration protocol for the isolation and quantification of α‐synuclein monomers, oligomers and fibrils: Towards improving experimental reproducibility in α‐synuclein research
por: Kumar, Senthil T., et al.
Publicado: (2020)

Acetylation discriminates disease-specific tau deposition
por: Chakraborty, Pijush, et al.
Publicado: (2023)

Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes
por: Ait-Bouziad, Nadine, et al.
Publicado: (2017)

Co-factor-free aggregation of tau into seeding-competent RNA-sequestering amyloid fibrils
por: Chakraborty, Pijush, et al.
Publicado: (2021)

Site‐Specific Phosphorylation of Huntingtin Exon 1 Recombinant Proteins Enabled by the Discovery of Novel Kinases
por: Chiki, Anass, et al.
Publicado: (2020)

Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties
por: Riguet, Nathan, et al.
Publicado: (2021)

Extending the applicability of P3D for structure determination of small molecules
por: Ibáñez de Opakua, Alain, et al.
Publicado: (2021)

Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity
por: Stephens, Amberley D., et al.
Publicado: (2020)

Ectopic Expression of AeNAC83, a NAC Transcription Factor from Abelmoschus esculentus, Inhibits Growth and Confers Tolerance to Salt Stress in Arabidopsis
por: Zhao, Xuan, et al.
Publicado: (2022)

Opportunities and challenges of alpha-synuclein as a potential biomarker for Parkinson’s disease and other synucleinopathies
por: Magalhães, Pedro, et al.
Publicado: (2022)

Nucleocapsid protein of SARS-CoV-2 phase separates into RNA-rich polymerase-containing condensates
por: Savastano, Adriana, et al.
Publicado: (2020)

GhNAC83 inhibits corm dormancy release by regulating ABA signaling and cytokinin biosynthesis in Gladiolus hybridus
por: Wu, Jian, et al.
Publicado: (2019)

The Gluten Gene: Unlocking the Understanding of Gluten Sensitivity and Intolerance
por: Asri, Nastaran, et al.
Publicado: (2021)

Molecular Basis of Small-Molecule Binding to α-Synuclein
por: Robustelli, Paul, et al.
Publicado: (2022)

Membrane-embedded TSPO: an NMR view
por: Rivière, Gwladys, et al.
Publicado: (2020)

Isolation of ORCTL3 in a novel genetic screen for tumor-specific apoptosis inducers
por: Irshad, Shazia, et al.
Publicado: (2009)

Interspecies microbiome transplantation recapitulates microbial acquisition in mosquitoes
por: Coon, Kerri L., et al.
Publicado: (2022)

Recapitulation
Publicado: (1866)

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models
por: Hegde, Ramanath Narayana, et al.
Publicado: (2020)

Proline/arginine dipeptide repeat polymers derail protein folding in amyotrophic lateral sclerosis
por: Babu, Maria, et al.
Publicado: (2021)

Contributions of the N‐terminal intrinsically disordered region of the severe acute respiratory syndrome coronavirus 2 nucleocapsid protein to RNA‐induced phase separation
por: Zachrdla, Milan, et al.
Publicado: (2022)

Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization
por: Dominguez-Meijide, Antonio, et al.
Publicado: (2020)

What about faculty?
por: Lashuel, Hilal A
Publicado: (2020)

Remembering John Q Trojanowski, in his own words: A life dedicated to discovering building blocks and using them to build bridges of knowledge, collaboration, and discovery
por: Lashuel, Hilal A.
Publicado: (2022)

Artificial intelligence–coupled plasmonic infrared sensor for detection of structural protein biomarkers in neurodegenerative diseases
por: Kavungal, Deepthy, et al.
Publicado: (2023)

Metal ions shape α-synuclein
por: Moons, Rani, et al.
Publicado: (2020)

EXM 83-20 du 15/9/83
Publicado: (1983)

Visualizing alpha-synuclein and iron deposition in M83 mouse model of Parkinson’s disease in vivo
por: Straumann, Nadja, et al.
Publicado: (2023)

Pronounced α-Synuclein Pathology in a Seeding-Based Mouse Model Is Not Sufficient to Induce Mitochondrial Respiration Deficits in the Striatum and Amygdala
por: Burtscher, Johannes, et al.
Publicado: (2020)

Condensed-phase signaling can expand kinase specificity and respond to macromolecular crowding
por: Sang, Dajun, et al.
Publicado: (2022)

Effects of Detergent on α-Synuclein Structure: A Native MS-Ion Mobility Study
por: Moons, Rani, et al.
Publicado: (2020)

Determination of Complex Small‐Molecule Structures Using Molecular Alignment Simulation
por: Ibáñez de Opakua, Alain, et al.
Publicado: (2020)

Algorithms unlocked /
por: Cormen, Thomas H.
Publicado: (2013)

Unlock You
por: Wood, Beth
Publicado: (2019)

Unlocking the universe
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_0u9t2gbrhj5jgf08jjufhoiahm