Synthesis, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities, and molecular docking studies of a novel compound based on combination of flurbiprofen and isoniazide

Synthesis of a compound with balanced bioactivities against a specific target is always a challenging task. In this study, a novel compound (1) has been synthesized by combination of flurbiprofen and isoniazide and shows ∼2.5 times enhanced acetylcholinesterase (AChE) inhibition activity and ∼1.7 ti...

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Detalles Bibliográficos
Autores principales: Asghar, Amina, Yousuf, Muhammad, Fareed, Ghulam, Nazir, Rabia, Hassan, Abida, Maalik, Aneela, Noor, Tayyaba, Iqbal, Naseem, Rasheed, Lubna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054046/
https://www.ncbi.nlm.nih.gov/pubmed/35515452
http://dx.doi.org/10.1039/d0ra02339f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054046/
https://www.ncbi.nlm.nih.gov/pubmed/35515452
http://dx.doi.org/10.1039/d0ra02339f

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