Discovery of hydrazide-based pyridazino[4,5-b]indole scaffold as a new phosphoinositide 3-kinase (PI3K) inhibitor for breast cancer therapy

Herein, the mono and dialkylation of pyridazino[4,5-b]indole were achieved with a set of alkylating agents, including amyl bromide, allyl bromide, benzyl bromide and ethyl chloroacetate in the presence of K(2)CO(3)/acetone or KOH/DMSO. The hydrazinolysis of mono and di-esters 10 and 11 gave the targ...

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Detalles Bibliográficos
Autores principales: Sarhan, Ahmed A. M., Boraei, Ahmed T. A., Barakat, Assem, Nafie, Mohamed S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054070/
https://www.ncbi.nlm.nih.gov/pubmed/35515454
http://dx.doi.org/10.1039/d0ra02798g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054070/
https://www.ncbi.nlm.nih.gov/pubmed/35515454
http://dx.doi.org/10.1039/d0ra02798g

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