Cryo-EM structure of the human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand-binding specificity

Somatostatin is a peptide hormone that regulates endocrine systems by binding to G-protein-coupled somatostatin receptors. Somatostatin receptor 2 (SSTR2) is a human somatostatin receptor and is highly implicated in hormone disorders, cancers, and neurological diseases. Here, we report the high-reso...

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Detalles Bibliográficos
Autores principales: Heo, Yunseok, Yoon, Eojin, Jeon, Ye-Eun, Yun, Ji-Hye, Ishimoto, Naito, Woo, Hyeonuk, Park, Sam-Yong, Song, Ji-Joon, Lee, Weontae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054131/
https://www.ncbi.nlm.nih.gov/pubmed/35446253
http://dx.doi.org/10.7554/eLife.76823

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054131/
https://www.ncbi.nlm.nih.gov/pubmed/35446253
http://dx.doi.org/10.7554/eLife.76823

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