Quantifying chromosomal instability from intratumoral karyotype diversity using agent-based modeling and Bayesian inference

Chromosomal instability (CIN)—persistent chromosome gain or loss through abnormal mitotic segregation—is a hallmark of cancer that drives aneuploidy. Intrinsic chromosome mis-segregation rate, a measure of CIN, can inform prognosis and is a promising biomarker for response to anti-microtubule agents...

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Detalles Bibliográficos
Autores principales: Lynch, Andrew R, Arp, Nicholas L, Zhou, Amber S, Weaver, Beth A, Burkard, Mark E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054132/
https://www.ncbi.nlm.nih.gov/pubmed/35380536
http://dx.doi.org/10.7554/eLife.69799

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054132/
https://www.ncbi.nlm.nih.gov/pubmed/35380536
http://dx.doi.org/10.7554/eLife.69799

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