Contingency and selection in mitochondrial genome dynamics

High frequencies of mutant mitochondrial DNA (mtDNA) in human cells lead to cellular defects that are associated with aging and disease. Yet much remains to be understood about the dynamics of the generation of mutant mtDNAs and their relative replicative fitness that informs their fate within cells...

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Detalles Bibliográficos
Autores principales: Nunn, Christopher J, Goyal, Sidhartha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054137/
https://www.ncbi.nlm.nih.gov/pubmed/35404229
http://dx.doi.org/10.7554/eLife.76557