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LNA units present in [R(P)-PS]-(DNA#LNA) chimeras enhance the thermal stability of parallel duplexes and triplexes formed with (2′-OMe)-RNA strands

The results of CD measurements indicate that 2-4 LNA units distributed along 12 nt P-stereodefined phosphorothioate [R(P)-PS]-(DNA#LNA) chimeras impose a C3′-endo conformation on the 2′-deoxyribonucleosides. Under neutral and slightly acidic conditions homopurine [R(p)-PS]-(DNA#LNA) hybridizes with...

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Detalles Bibliográficos
Autores principales: Jastrzębska, Katarzyna, Mikołajczyk, Barbara, Guga, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054617/
https://www.ncbi.nlm.nih.gov/pubmed/35514591
http://dx.doi.org/10.1039/d0ra03934a