Cargando…

Over-representation of potential SP4 target genes within schizophrenia-risk genes

Reduction of Sp4 expression causes age-dependent hippocampal vacuolization and many other intermediate phenotypes of schizophrenia in Sp4 hypomorphic mice. Recent human genetic studies from both the Schizophrenia Exome Sequencing Meta-Analysis (SCHEMA) and the Genome-Wide Association Study (GWAS) va...

Descripción completa

Detalles Bibliográficos
Autor principal:	Zhou, Xianjin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Immediate Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054665/ https://www.ncbi.nlm.nih.gov/pubmed/34750502 http://dx.doi.org/10.1038/s41380-021-01376-8

Ejemplares similares

Rare tandem repeat expansions associate with genes involved in synaptic and neuronal signaling functions in schizophrenia
por: Wen, Jia, et al.
Publicado: (2022)

Genome-wide tandem repeat expansions contribute to schizophrenia risk
por: Mojarad, Bahareh A., et al.
Publicado: (2022)

Targeting the schizophrenia genome: a fast track strategy from GWAS to clinic
por: Lencz, T, et al.
Publicado: (2015)

Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction
por: Ayalew, M, et al.
Publicado: (2012)

Schizophrenia copy number variants and associative learning
por: Clifton, N E, et al.
Publicado: (2017)

Evidence that duplications of 22q11.2 protect against schizophrenia
por: Rees, E, et al.
Publicado: (2014)

Adjunctive raloxifene treatment improves attention and memory in men and women with schizophrenia
por: Weickert, T W, et al.
Publicado: (2015)

Neurotrophin receptor activation rescues cognitive and synaptic abnormalities caused by hemizygosity of the psychiatric risk gene Cacna1c
por: Tigaret, Cezar M., et al.
Publicado: (2021)

Long-read sequencing reveals the complex splicing profile of the psychiatric risk gene CACNA1C in human brain
por: Clark, Michael B., et al.
Publicado: (2019)

Schizophrenia is defined by cell-specific neuropathology and multiple neurodevelopmental mechanisms in patient-derived cerebral organoids
por: Notaras, Michael, et al.
Publicado: (2021)

De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia
por: Kirov, G, et al.
Publicado: (2012)

GWAS-identified bipolar disorder risk allele in the FADS1/2 gene region links mood episodes and unsaturated fatty acid metabolism in mutant mice
por: Yamamoto, Hirona, et al.
Publicado: (2023)

Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci
por: Smith, D J, et al.
Publicado: (2016)

A psychiatric disease-related circular RNA controls synaptic gene expression and cognition
por: Zimmerman, Amber J., et al.
Publicado: (2020)

Whole-genome sequencing suggests a chemokine gene cluster that modifies age at onset in familial Alzheimer's disease
por: Lalli, M A, et al.
Publicado: (2015)

A projection for psychiatry in the post-COVID-19 era: potential trends, challenges, and directions
por: Türközer, Halide Bilge, et al.
Publicado: (2020)

DNA sequence-level analyses reveal potential phenotypic modifiers in a large family with psychiatric disorders
por: Ryan, Niamh M., et al.
Publicado: (2018)

A rare missense mutation in CHRNA4 associates with smoking behavior and its consequences
por: Thorgeirsson, T E, et al.
Publicado: (2016)

Precision medicine for mood disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs
por: Le-Niculescu, H., et al.
Publicado: (2021)

Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach
por: Niculescu, A B, et al.
Publicado: (2015)

Blood biomarkers for memory: toward early detection of risk for Alzheimer disease, pharmacogenomics, and repurposed drugs
por: Niculescu, A. B., et al.
Publicado: (2019)

Towards precision medicine for anxiety disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs
por: Roseberry, K., et al.
Publicado: (2023)

Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci
por: Deak, Joseph D., et al.
Publicado: (2022)

Novel upregulation of amyloid-β precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5′-untranslated region: Implications in Alzheimer’s disease
por: Long, Justin M., et al.
Publicado: (2018)

COVID-19 risk and outcomes in patients with substance use disorders: analyses from electronic health records in the United States
por: Wang, Quan Qiu, et al.
Publicado: (2020)

Ucp2-dependent microglia-neuronal coupling controls ventral hippocampal circuit function and anxiety-like behavior
por: Yasumoto, Yuki, et al.
Publicado: (2021)

The translocator protein (TSPO) is prodromal to mitophagy loss in neurotoxicity
por: Frison, Michele, et al.
Publicado: (2021)

Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry
por: Sanchez-Roige, Sandra, et al.
Publicado: (2021)

Stress-related emotional and behavioural impact following the first COVID-19 outbreak peak
por: Benjamin, Asaf, et al.
Publicado: (2021)

The acute phase protein lactoferrin is a key feature of Alzheimer’s disease and predictor of Aβ burden through induction of APP amyloidogenic processing
por: Tsatsanis, Andrew, et al.
Publicado: (2021)

CRH(CeA→VTA) inputs inhibit the positive ensembles to induce negative effect of opiate withdrawal
por: Jiang, Changyou, et al.
Publicado: (2021)

Disruption of NEUROD2 causes a neurodevelopmental syndrome with autistic features via cell-autonomous defects in forebrain glutamatergic neurons
por: Runge, Karen, et al.
Publicado: (2021)

Accumbens D2-MSN hyperactivity drives antipsychotic-induced behavioral supersensitivity
por: Kruyer, Anna, et al.
Publicado: (2021)

Using induced pluripotent stem cells to investigate human neuronal phenotypes in 1q21.1 deletion and duplication syndrome
por: Chapman, Gareth, et al.
Publicado: (2021)

Effects of placebo administration on immune mechanisms and relationships with central endogenous opioid neurotransmission
por: Prossin, Alan, et al.
Publicado: (2021)

Psychological responses among nurses caring for patients with COVID-19: a comparative study in China
por: Ren, Honggang, et al.
Publicado: (2021)

Visual analysis of geocoded twin data puts nature and nurture on the map
por: Davis, O S P, et al.
Publicado: (2012)

Corticotropin-releasing hormone exerts direct effects on neuronal progenitor cells: implications for neuroprotection
por: Koutmani, Y, et al.
Publicado: (2013)

Discovery and validation of blood biomarkers for suicidality
por: Le-Niculescu, H, et al.
Publicado: (2013)

Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N=112 151)
por: Davies, G, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_7hmtmhacs5t429v58ug72nce1c