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Thompson loop: opportunities for antitubercular drug design by targeting the weak spot in demethylmenaquinone methyltransferase protein

Drug-resistant Tuberculosis (TB) has remained the top global health challenge, with a yearly estimation of 10 million infections and 1.5 million deaths in humans. Demethylmenaquinone methyltransferase (menG) catalyzes demethylmenaquinone conversion to menaquinone (MK) that is implicated in the TB pa...

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Detalles Bibliográficos
Autores principales: Adewumi, Adeniyi T., Soremekun, Opeyemi S., Ajadi, Mary B., Soliman, Mahmoud E. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054810/
https://www.ncbi.nlm.nih.gov/pubmed/35520325
http://dx.doi.org/10.1039/d0ra03206a