CFTR mRNAs with nonsense codons are degraded by the SMG6-mediated endonucleolytic decay pathway

Approximately 10% of cystic fibrosis patients harbor nonsense mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene which can generate nonsense codons in the CFTR mRNA and subsequently activate the nonsense-mediated decay (NMD) pathway resulting in rapid mRNA degradation....

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Detalles Bibliográficos
Autores principales: Sanderlin, Edward J., Keenan, Melissa M., Mense, Martin, Revenko, Alexey S., Monia, Brett P., Guo, Shuling, Huang, Lulu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054838/
https://www.ncbi.nlm.nih.gov/pubmed/35487895
http://dx.doi.org/10.1038/s41467-022-29935-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054838/
https://www.ncbi.nlm.nih.gov/pubmed/35487895
http://dx.doi.org/10.1038/s41467-022-29935-9

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