Mechanism of integrin activation by talin and its cooperation with kindlin

Talin-induced integrin binding to extracellular matrix ligands (integrin activation) is the key step to trigger many fundamental cellular processes including cell adhesion, cell migration, and spreading. Talin is widely known to use its N-terminal head domain (talin-H) to bind and activate integrin,...

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Detalles Bibliográficos
Autores principales: Lu, Fan, Zhu, Liang, Bromberger, Thomas, Yang, Jun, Yang, Qiannan, Liu, Jianmin, Plow, Edward F., Moser, Markus, Qin, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054839/
https://www.ncbi.nlm.nih.gov/pubmed/35488005
http://dx.doi.org/10.1038/s41467-022-30117-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054839/
https://www.ncbi.nlm.nih.gov/pubmed/35488005
http://dx.doi.org/10.1038/s41467-022-30117-w

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