PHD2 deletion in endothelial or arterial smooth muscle cells reveals vascular cell type-specific responses in pulmonary hypertension and fibrosis

Hypoxia plays an important regulatory role in the vasculature to adjust blood flow to meet metabolic requirements. At the level of gene transcription, the responses are mediated by hypoxia-inducible factor (HIF) the stability of which is controlled by the HIF prolyl 4-hydroxylase-2 (PHD2). In the lu...

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Detalles Bibliográficos
Autores principales: Elamaa, Harri, Kaakinen, Mika, Nätynki, Marjut, Szabo, Zoltan, Ronkainen, Veli-Pekka, Äijälä, Ville, Mäki, Joni M., Kerkelä, Risto, Myllyharju, Johanna, Eklund, Lauri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054891/
https://www.ncbi.nlm.nih.gov/pubmed/34997404
http://dx.doi.org/10.1007/s10456-021-09828-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054891/
https://www.ncbi.nlm.nih.gov/pubmed/34997404
http://dx.doi.org/10.1007/s10456-021-09828-z

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