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A Zn(II) complex of ornidazole with decreased nitro radical anions that is still highly active on Entamoeba histolytica
A monomeric complex of Zn(II) with ornidazole [Zn(Onz)(2)Cl(2)] decreases formation of the nitro-radical anion (R–NO(2)˙(−)), and this is realized by recording it in an enzyme assay using xanthine oxidase, which is a model nitro-reductase. Although the formation of R–NO(2)˙(−) is essential for drug...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054926/ https://www.ncbi.nlm.nih.gov/pubmed/35520323 http://dx.doi.org/10.1039/d0ra02597f |