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Teriflunomide treatment exacerbates cardiac ischemia reperfusion injury in isolated rat hearts

PURPOSE: Previous work suggests that Dihydroorotate dehydrogenase (DHODH) inhibition via teriflunomide (TERI) may provide protection in multiple disease models. To date, little is known about the effect of TERI on the heart. This study was performed to assess the potential effects of TERI on cardiac...

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Detalles Bibliográficos
Autores principales: Alexander, Emily Davis, Aldridge, Jessa L., Burleson, T. Samuel, Frasier, Chad R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055010/
https://www.ncbi.nlm.nih.gov/pubmed/35488973
http://dx.doi.org/10.1007/s10557-022-07341-z