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New chalcone derivatives: synthesis, antiviral activity and mechanism of action

In this work, twenty-eight chalcone derivatives containing a purine (sulfur) ether moiety were synthesized and their antiviral activities were evaluated. Biological results showed that compound 5d exhibited outstanding inactive activity against tobacco mosaic virus (TMV) in vivo (EC(50) = 65.8 μg mL...

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Detalles Bibliográficos
Autores principales: Fu, Yun, Liu, Dan, Zeng, Huanan, Ren, Xiaoli, Song, Baoan, Hu, Deyu, Gan, Xiuhai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055036/
https://www.ncbi.nlm.nih.gov/pubmed/35516226
http://dx.doi.org/10.1039/d0ra03684f