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Reference-free cell type deconvolution of multi-cellular pixel-resolution spatially resolved transcriptomics data

Recent technological advancements have enabled spatially resolved transcriptomic profiling but at multi-cellular pixel resolution, thereby hindering the identification of cell-type-specific spatial patterns and gene expression variation. To address this challenge, we develop STdeconvolve as a refere...

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Detalles Bibliográficos
Autores principales: Miller, Brendan F., Huang, Feiyang, Atta, Lyla, Sahoo, Arpan, Fan, Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055051/
https://www.ncbi.nlm.nih.gov/pubmed/35487922
http://dx.doi.org/10.1038/s41467-022-30033-z