Electrochemically driven, cobalt–carbon bond-mediated direct intramolecular cyclic and acyclic perfluoroalkylation of (hetero)arenes using X(CF(2))(4)X

A proof-of-concept for the one-step, synthetically challenging cyclic and acyclic perfluoroalkylation of (hetero)arenes driven by the valence change of a vitamin B(12) derivative as a cobalt catalyst in the presence of fluoroalkylating reagents (X(CF(2))(4)X) is presented. The consecutive formation...

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Detalles Bibliográficos
Autores principales: Cui, Luxia, Ono, Toshikazu, Hossain, Md. Jakir, Hisaeda, Yoshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055166/
https://www.ncbi.nlm.nih.gov/pubmed/35517485
http://dx.doi.org/10.1039/d0ra05295g
Descripción
Sumario:A proof-of-concept for the one-step, synthetically challenging cyclic and acyclic perfluoroalkylation of (hetero)arenes driven by the valence change of a vitamin B(12) derivative as a cobalt catalyst in the presence of fluoroalkylating reagents (X(CF(2))(4)X) is presented. The consecutive formation of cobalt–carbon bonds and generation of fluoroalkyl radicals by homolysis are the key steps for the reaction to proceed.

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